Genotype 3

    1. G3 naïve NON-CIRRHOTIC
      1. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily for 12 weeks à 98% SVR12 (ASTRAL-3)
      2. Mavyret [Glecaprevir and Pibrentasvir 3-tablet coformulation] 3 tabs daily [with food] for 8 weeks à 95% SVR12 (ENDURANCE-3)

     

    1. G3 naïve COMPENSATED CIRRHOTIC
      1. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily for 12 weeks à 93% SVR12 (ASTRAL-3)
      2. Mavyret [Glecaprevir and Pibrentasvir 3-tablet coformulation] 3 tabs daily [with food] for 12 weeks à 100% SVR12 (SURVEYOR-II)

     

    1. G3 prior treatment failure to PEG + RBV NON-CIRRHOTIC
      1. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily for 12 weeks à 95% SVR12 (ASTRAL- 3) AND 97% SVR12 (POLARIS-2)

     

    1. G3 prior treatment failure to PEG + RBV COMPENSATED CIRRHOTIC
      1. Zepatier [Elbasvir and Grazoprevir fixed dose combination] 1tab daily + SOF for 12 weeks à 100% SVR12 (C-ISLE)
      2. Vosevi [VEL/SOF/VOX daily fixed dose combination] 1 tab daily for 12 weeks à ?% SVR12 (POLARIS-3)

     

    1. G3 prior treatment failure to DAA-EXPERIENCED [INCLUDING NS5A-INHIBITORS] NON-CIRRHOTIC OR COMPENSATED CIRRHOTIC
      1. Vosevi [VEL/SOF/VOX daily fixed dose combination] 1 tab daily for 12 weeks à SVR12 96% (POLARIS-4) + SVR12 95% (POLARIS-1)

     

    For patients with prior NS5A inhibitor failure and cirrhosis, weight-based ribavirin [RBV] is recommended.

     

    1. G3 DECOMPENSATED CIRRHOTIC
      1. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily + RBV WBD for 12 weeks à 85% SVR12 [ASTRAL-4]
      2. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily for 24 weeks à ?% SVR12 – RBV Ineligible
      3. SOF 400MG QD + DCV 60 MG QD + RBV WBD for 12 weeks à 70% SVR12 (FOSTER UK EAP GROUP)
      4. SOF 400MG QD + DCV 60 MG QD for 12 weeks à 71% SVR12 (FOSTER UK EAP GROUP)

     

    SOF = Sofosbuvir [Sovaldi] – NS5B nucleotide analog polymerase inhibitor

    VEL = Velpatasvir [100 mg daily] – NS5A inhibitor

    DCV = Daclatasvir [60 mg daily] – NS5A inhibitor

    Mavyret = Glecaprevir [300 mg] – NS3/4A protease inhibitor + Pibrentasvir [120 mg] – – NS5A inhibitor

    Vosevi = Sofosbuvir [400 mg] + Velpatasvir [100 mg] + Voxilaprevir [100mg] NS3/4A protease inhibitor

    Zepatier = Elbasvir [50 mg] – NS5A inhibitor + Grazoprevir [100 mg daily] – NS3/4A protease inhibitor

    RBV = Ribavirin [RIBAPAK/MODERIBA/RIBAVIRIN] [Weight <75 kg – 1000 mg daily; >75 kg – 1200 mg daily]

Share on FacebookShare on Google+Share on LinkedInTweet about this on TwitterEmail this to someonePrint this page