Genotype 5 or 6

  1. G5 or 6 naïve or treatment experienced NON-CIRRHOTIC
    1. Harvoni [LDV/SOF daily fixed dose combination] 1 tab daily for 12 weeks –> 95% SVR12 [Abergel; EASL 2015] and 96% SVR12 [Kohler, 2014] respectively
    2. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily for 12 weeks –> 96% [G5] and 100% [G6] SVR12 (ASTRAL-1)

 

  1. G5 or 6 naïve or treatment experienced COMPENSATED CIRRHOTIC
    1. Harvoni [LDV/SOF daily fixed dose combination] 1 tab daily + RBV 1000-1200mg daily for 12 weeks –> ?% SVR12
    2. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily for 12 weeks –> 96% [G5] and 100% [G6] SVR12 (ASTRAL-1)

Clinic Visits and Labs                                                                                                                  

  1. Initiation of Therapy
  2. Week 2 – CBC, CMP
  3. Week 4 – CBC, CMP, HCV RNA PCR quantitative & hCG [If RBV]
  4. Week 8 – CBC, CMP
  5. Week 12 – CBC, CMP, HCV RNA PCR quantitative & hCG
  6. Week 4 Post Therapy – CBC, CMP, HCV RNA PCR quantitative & hCG
  7. Week 12 Post Therapy – CBC, CMP, HCV RNA PCR quantitative & hCG – SVR12

SOF = Sofosbuvir [Solvaldi] – NS5B nucleotide analog polymerase inhibitor

VEL = Velpatasvir [100 mg daily] – NS5A inhibitor

LDV = Ledipasvir [90 mg daily] – NS5A inhibitor

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