Post Liver Transplant

  1. G1, 4, 5 or 6 NAÏVE AND TREATMENT EXPERIENCED INFECTIONS IN THE ALLOGRAFT WITHOUT CIRRHOSIS
    1. Mavyret [Glecaprevir and Pibrentasvir 3-tablet coformulation] 3 tabs daily [with food] for 12 weeks à 98% SVR12 (MAGELLAN-2)
    2. Harvoni [LDV/SOF daily fixed dose combination] 1 tab daily + RBV WBD BID for 12 weeks à 96% SVR12 & for 24 weeks à 98% SVR12 (SOLAR-1)

  1. G1, 4, 5 or 6 NAÏVE AND TREATMENT EXPERIENCED INFECTIONS IN THE ALLOGRAFT WITH COMPENSATED CIRRHOSIS
    1. Harvoni [LDV/SOF daily fixed dose combination] 1 tab daily + RBV WBD BID for 12 weeks à 96% SVR12 (SOLAR-1)

 

  1. G1, 4, 5 or 6 NAÏVE AND TREATMENT EXPERIENCED INFECTIONS IN THE ALLOGRAFT WITH DECOMPENSATED CIRRHOSIS
    1. Harvoni [LDV/SOF daily fixed dose combination] 1 tab daily + with low initial dose of ribavirin (600 mg, increase as tolerated) for 12 weeks à 86% SVR12 [CLASS B] AND 60% [CLASS C] (SOLAR-1)

 

  1. G2 or 3 NAÏVE AND TREATMENT EXPERIENCED INFECTIONS IN THE ALLOGRAFT WITHOUT CIRRHOSIS
    1. Mavyret [Glecaprevir and Pibrentasvir 3-tablet coformulation] 3 tabs daily [with food] for 12 weeks à 98% SVR12 (MAGELLAN-2)
    2. SOF 400MG QD + DCV 60 MG QD + low initial dose of ribavirin (600 mg, increase as tolerated) for 12 weeks à 94% SVR12 [ALLY-1]

 

  1. G2 or 3 NAÏVE AND TREATMENT EXPERIENCED INFECTIONS IN THE ALLOGRAFT WITH COMPENSATED CIRRHOSIS
    1. SOF 400MG QD + DCV 60 MG QD + low initial dose of ribavirin (600 mg, increase as tolerated) for 12 weeks à 94% SVR12 [ALLY-1]

 

  1. G2 or 3 NAÏVE AND TREATMENT EXPERIENCED INFECTIONS IN THE ALLOGRAFT WITH DECOMPENSATED CIRRHOSIS
    1. SOF 400MG QD + DCV 60 MG QD + low initial dose of ribavirin (600 mg, increase as tolerated) for 12 weeks à 94% SVR12 [ALLY-1]
    2. Epclusa [VEL/SOF daily fixed dose combination] 1 tab daily + with low initial dose of ribavirin (600 mg, increase as tolerated) for 12 weeks à ?% SVR12

 

SOF = Sofosbuvir [Sovaldi] [400 mg daily] – NS5B nucleotide analog polymerase inhibitor

RBV = Ribavirin [RIBAPAK/MODERIBA/RIBAVIRIN] [Weight <75 kg – 1000 mg daily; >75 kg – 1200 mg daily] [Escalating dose of RBV – Initial dose most commonly 600-800 mg daily]

LDV = Ledipasvir [90 mg daily] – NS5A inhibitor

VEL = Velpatasvir [100 mg daily] – NS5A inhibitor

DCV = Daclatasvir [60 mg daily] [DAKLINZA] – NS5A inhibitor

Mavyret = Glecaprevir [300 mg] – NS3/4A protease inhibitor + Pibrentasvir [120 mg] – – NS5A inhibitor

Share on FacebookShare on Google+Share on LinkedInTweet about this on TwitterEmail this to someonePrint this page